| Primary Identifier | MGI:1920895 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 212880 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46). PHENOTYPE: Mice homozygous for a knock-out allele show complete prenatal lethality. Heterozygotes are viable and reach adulthood but exhibit smaller body size, increased macrophage cytokine production, increased interferon-beta secretion, and decreased susceptibility to vesicular stomatitis virus infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
