| First Author | Staeheli P | Year | 1984 |
| Journal | Virology | Volume | 132 |
| Issue | 2 | Pages | 456-61 |
| PubMed ID | 6322423 | Mgi Jnum | J:7365 |
| Mgi Id | MGI:55836 | Doi | 10.1016/0042-6822(84)90050-3 |
| Citation | Staeheli P, et al. (1984) Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology 132(2):456-61 |
| abstractText | In cells derived from congenic BALB.A2G-Mx mice carrying the resistance gene Mx, but not in cells from BALB/c mice lacking Mx, mouse interferons alpha and beta induced the synthesis of a unique cellular protein that was associated with an efficient antiviral state with selectivity for influenza viruses. In contrast, native or recombinant mouse interferon gamma failed to efficiently protect Mx-bearing cells against influenza viruses and did not noticeably induce the synthesis of the Mx-associated protein, although interferon gamma was as effective as interferons alpha and beta in protecting BALB.A2G-Mx and BALB/c cells against the rhabdovirus VSV. These results demonstrate that different types of interferons differentially regulate the expression of the Mx gene and thereby induce distinct antiviral states. |
