| First Author | Hamilton SE | Year | 2006 |
| Journal | Nat Immunol | Volume | 7 |
| Issue | 5 | Pages | 475-81 |
| PubMed ID | 16604076 | Mgi Jnum | J:112558 |
| Mgi Id | MGI:3662779 | Doi | 10.1038/ni1326 |
| Citation | Hamilton SE, et al. (2006) The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells. Nat Immunol 7(5):475-81 |
| abstractText | Antigen-specific memory T cells are a critical component of protective immunity because of their increased frequency and enhanced reactivity after restimulation. However, it is unclear whether 'memory-like' T cells generated during lymphopenia-induced homeostatic proliferation can also offer protection against pathogens. Here we show that homeostatic proliferation-induced memory (HP-memory) CD8(+) T cells controlled bacterial infection as effectively as 'true' memory CD8(+) T cells, but their protective capacity required the presence of CD4(+) T cells during homeostatic proliferation. The necessity for CD4 help was overcome, however, if the HP-memory CD8(+) T cells lacked expression of TRAIL (tumor necrosis factor-related apoptosis-inducing ligand; also called Apo-2L). Thus, like conventional CD8(+) memory T cells, the protective function of HP-memory CD8(+) T cells shows dependence on CD4(+) T cell help. |
