| First Author | Hosking BM | Year | 1995 |
| Journal | Nucleic Acids Res | Volume | 23 |
| Issue | 14 | Pages | 2626-8 |
| PubMed ID | 7651823 | Mgi Jnum | J:28005 |
| Mgi Id | MGI:75639 | Doi | 10.1093/nar/23.14.2626 |
| Citation | Hosking BM, et al. (1995) Trans-activation and DNA-binding properties of the transcription factor, Sox-18. Nucleic Acids Res 23(14):2626-8 |
| abstractText | Sox-18 is a member of the Sox multi-gene family (Sry-related HMG-box gene). We have bacterially expressed this 378 amino acid protein and demonstrated sequence-specific binding to the Sox DNA-binding motif AACAAAG. A distinct 95 amino acid activation domain was mapped in Sox-18 using GAL4-Sox-18 fusions (amino acids 160-225). Furthermore, Sox-18 was capable of trans-activating gene expression through the AACAAA motif. Our results suggest that Sox-18 functions as a classical trans-activator of gene expression. |
