| First Author | Jansen NA | Year | 2020 |
| Journal | Ann Clin Transl Neurol | Volume | 7 |
| Issue | 1 | Pages | 132-138 |
| PubMed ID | 31880072 | Mgi Jnum | J:285436 |
| Mgi Id | MGI:6392976 | Doi | 10.1002/acn3.50971 |
| Citation | Jansen NA, et al. (2020) First FHM3 mouse model shows spontaneous cortical spreading depolarizations. Ann Clin Transl Neurol 7(1):132-138 |
| abstractText | Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events - the electrophysiological correlate of the migraine aura - in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V-mutated alpha1 subunits in voltage-gated NaV 1.1 sodium channels (Scn1a(L263V) ). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature. |
