| First Author | Dickinson ME | Year | 1990 |
| Journal | Genomics | Volume | 6 |
| Issue | 3 | Pages | 505-20 |
| PubMed ID | 1970330 | Mgi Jnum | J:10440 |
| Mgi Id | MGI:58891 | Doi | 10.1016/0888-7543(90)90480-i |
| Citation | Dickinson ME, et al. (1990) Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. Genomics 6(3):505-20 |
| abstractText | Chromosomal locations have been assigned to seven members of the TGF-beta superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-beta superfamily map to eight different chromosomes, indicating that the TGF-beta family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-beta-related genes. |
