| First Author | Guo L | Year | 2014 |
| Journal | FEBS Open Bio | Volume | 4 |
| Pages | 420-5 | PubMed ID | 24918056 |
| Mgi Jnum | J:244350 | Mgi Id | MGI:5913129 |
| Doi | 10.1016/j.fob.2014.04.004 | Citation | Guo L, et al. (2014) Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm. FEBS Open Bio 4:420-5 |
| abstractText | The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway. KSR2 mediates germline mpk-1 (Caenorhabditis elegans ERK) phosphorylation in C. elegans and has been implicated the regulation of meiosis. KSR2(-/-) mice exhibit metabolic abnormalities and are reproductively impaired. The role of KSR2 in meiosis and fertility in mice has yet to be elucidated. Here, we describe a novel truncated KSR2 mRNA identified in mouse testes (T-KSR2). Further analysis demonstrates T-KSR2 is specific to mouse testes and mature sperm cells. The detection of T-KSR2 may enhance our understanding of mechanisms controlling spermatogenesis and fertility. |
