| First Author | Koike N | Year | 1998 |
| Journal | FEBS Lett | Volume | 441 |
| Issue | 3 | Pages | 427-31 |
| PubMed ID | 9891984 | Mgi Jnum | J:51960 |
| Mgi Id | MGI:1327507 | Doi | 10.1016/s0014-5793(98)01597-x |
| Citation | Koike N, et al. (1998) Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1. FEBS Lett 441(3):427-31 |
| abstractText | We have identified novel mammalian homologues of a Drosophila clock gene, timeless, and designated them as human TIMELESS1 (hTIM1) and mouse Timeless1 (mTim1), respectively. These genes mere mapped by FISH to chromosomal regions 12q12-13 in human and 10D3 in mouse. The deduced amino acid sequences of hTim1 and mTim1 proteins mere 1208 and 1197 amino acids in length and shared 83% identity. Northern blot analysis identified a single transcript of 4.5 kb expressed widely in many tissues examined. Unlike the Drosophila counterpart, the levels of the mTim1 transcript exhibited no prominent circadian oscillation in the mouse brain. (C) 1998 Federation of European Biochemical Societies. |
