| First Author | Ohno I | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 228 |
| Issue | 2 | Pages | 411-4 |
| PubMed ID | 8920928 | Mgi Jnum | J:36856 |
| Mgi Id | MGI:84269 | Doi | 10.1006/bbrc.1996.1675 |
| Citation | Ohno I, et al. (1996) A cDNA cloning of human AEBP1 from primary cultured osteoblasts and its expression in a differentiating osteoblastic cell line. Biochem Biophys Res Commun 228(2):411-4 |
| abstractText | By comparing lists of 3'-directed partial cDNA sequences (gene signatures) randomly collected from various tissues, genes uniquely expressed in individual tissue can be identified. A full length cDNA clone, corresponding to one such gene signature, unique to human osteoblast and adipose tissue, was isolated. This cDNA clone encodes a 845-amino acid protein that is almost identical to the mouse adipocyte transcription factor AEBP1 except that it has additional 105 amino acids in the N terminus. A northern hybridization showed that in the differentiating murine osteoblastic cell line, AEBP1 is also expressed but that it is shut off in the final calcification phase, suggesting a transcriptional repressive effect on genes for bone formation. |
