| First Author | Schwarz M | Year | 2001 |
| Journal | J Lipid Res | Volume | 42 |
| Issue | 11 | Pages | 1801-11 |
| PubMed ID | 11714849 | Mgi Jnum | J:72737 |
| Mgi Id | MGI:2153504 | Citation | Schwarz M, et al. (2001) Genetic analysis of intestinal cholesterol absorption in inbred mice. J Lipid Res 42(11):1801-11 |
| abstractText | A genetic mapping strategy was employed to identify chromosomal regions harboring genes that influence the absorption of intestinal cholesterol in the mouse. Analysis of seven inbred strains of male mice (129P3, AKR, BALB/c, C3H/He, C57BL/6, DBA/2, and SJL, all from Jackson Laboratories) revealed substantial differences in their abilities to absorb a bolus of cholesterol delivered by gavage. Crosses between high (AKR, 129) and low (DBA/2, SJL) absorbing strains revealed evidence for the presence of dominant genes that increase and decrease cholesterol absorption. Backcrosses between F(1) offspring and parental strains (DBA/2xAKD2F(1) and 129xSJL129F(1)) followed by linkage analyses revealed four quantitative trait loci that influenced cholesterol absorption. Analyses of recombinant inbred strains identified an additional three loci affecting this phenotype.These seven quantitative trait loci, which map to different chromosomes and are termed Cholesterol absorption 1-7 (Chab1-7) loci, together influence the absorption of intestinal cholesterol in mice and are likely to be involved in different steps of this complex pathway. |
