| First Author | Smyth MJ | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 3 | Pages | 1350-3 |
| PubMed ID | 10415034 | Mgi Jnum | J:56397 |
| Mgi Id | MGI:1340917 | Doi | 10.4049/jimmunol.163.3.1350 |
| Citation | Smyth MJ, et al. (1999) Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice. J Immunol 163(3):1350-3 |
| abstractText | We have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both NK cell-mediated tumor rejection and protection from experimental metastases were significantly compromised in LT-alpha- deficient mice. Analysis of LT-alpha-deficient mice revealed that the absolute number of alpha beta TCR- NK1.1(+) NK cells was reduced in bone marrow and thymus, but with overall proportional decreases in other hemopoietic organs. In addition, the antitumor potential of alpha beta TCR- NK1.1(+) cells, as determined by their lytic capacity and perforin expression, was reduced 1.5- to 3-fold in LT-alpha-deficient mice, as compared with wild-type mice. Combined defects in NK cell development and effector function contribute to compromised NK cell antitumor function in LT-alpha-deficient mice. |
