| First Author | Zhou CJ | Year | 2020 |
| Journal | Biochem Biophys Res Commun | Volume | 526 |
| Issue | 3 | Pages | 647-653 |
| PubMed ID | 32248972 | Mgi Jnum | J:306111 |
| Mgi Id | MGI:6713419 | Doi | 10.1016/j.bbrc.2020.03.138 |
| Citation | Zhou CJ, et al. (2020) Non-neural surface ectodermal rosette formation and F-actin dynamics drive mammalian neural tube closure. Biochem Biophys Res Commun 526(3):647-653 |
| abstractText | The mechanisms underlying mammalian neural tube closure remain poorly understood. We report a unique cellular process involving multicellular rosette formation, convergent cellular protrusions, and F-actin cable network of the non-neural surface ectodermal cells encircling the closure site of the posterior neuropore, which are demonstrated by scanning electron microscopy and genetic fate mapping analyses during mouse spinal neurulation. These unique cellular structures are severely disrupted in the surface ectodermal transcription factor Grhl3 mutants that exhibit fully penetrant spina bifida. We propose a novel model of mammalian neural tube closure driven by surface ectodermal dynamics, which is computationally visualized. |
