| First Author | Dobenecker MW | Year | 2020 |
| Journal | FEBS Lett | Volume | 594 |
| Issue | 20 | Pages | 3324-3337 |
| PubMed ID | 32862441 | Mgi Jnum | J:298767 |
| Mgi Id | MGI:6488806 | Doi | 10.1002/1873-3468.13903 |
| Citation | Dobenecker MW, et al. (2020) The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice. FEBS Lett 594(20):3324-3337 |
| abstractText | Humoral immunity in mammals relies on the function of two developmentally and functionally distinct B-cell subsets-B1 and B2 cells. While B2 cells are responsible for the adaptive response to environmental antigens, B1 cells regulate the production of polyreactive and low-affinity antibodies for innate humoral immunity. The molecular mechanism of B-cell specification into different subsets is understudied. In this study, we identified lysine methyltransferase NSD2 (MMSET/WHSC1) as a critical regulator of B1 cell development. In contrast to its minor impact on B2 cells, deletion of the catalytic domain of NSD2 in primary B cells impairs the generation of B1 lineage. Thus, NSD2, a histone H3 K36 dimethylase, is the first-in-class epigenetic regulator of a B-cell lineage in mice. |
