| Primary Identifier | MGI:1345147 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 23797 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). PHENOTYPE: Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
