| First Author | Kupz A | Year | 2012 |
| Journal | Nat Immunol | Volume | 13 |
| Issue | 2 | Pages | 162-9 |
| PubMed ID | 22231517 | Mgi Jnum | J:181212 |
| Mgi Id | MGI:5309077 | Doi | 10.1038/ni.2195 |
| Citation | Kupz A, et al. (2012) NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8 T cells. Nat Immunol 13(2):162-9 |
| abstractText | Memory T cells exert antigen-independent effector functions, but how these responses are regulated is unclear. We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells (DCs) and host protective interferon-gamma (IFN-gamma) secretion by noncognate memory CD8(+) T cells, which could be activated by Salmonella enterica serovar Typhimurium, Yersinia pseudotuberculosis and Pseudomonas aeruginosa. We show that CD8alpha(+) DCs were particularly efficient at sensing bacterial flagellin through NLRC4 inflammasomes. Although this activation released interleukin 18 (IL-18) and IL-1beta, only IL-18 was required for IFN-gamma production by memory CD8(+) T cells. Conversely, only the release of IL-1beta, but not IL-18, depended on priming signals mediated by Toll-like receptors. These findings provide a comprehensive mechanistic framework for the regulation of noncognate memory T cell responses during bacterial immunity. |
