| Primary Identifier | MGI:1926156 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 78906 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable actin filament binding activity. Predicted to be involved in several processes, including establishment of centrosome localization; microtubule cytoskeleton organization involved in mitosis; and regulation of protein localization to cell cortex. Predicted to act upstream of or within cell division. Predicted to be located in cytoskeleton; intracellular membrane-bounded organelle; and plasma membrane. Predicted to colocalize with cortical actin cytoskeleton; focal adhesion; and mitotic spindle astral microtubule end. Is expressed in gut. Orthologous to human MISP (mitotic spindle positioning). PHENOTYPE: Mice homozygous for a knock-out allele exhibit exacerbated dextran sulfate sodium (DSS)-induced colitis with significant increases in weight loss, more severe symptoms (bloody stools and diarrhea), and extensive crypt loss. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
