| First Author | Tam SJ | Year | 2012 |
| Journal | Dev Cell | Volume | 22 |
| Issue | 2 | Pages | 403-17 |
| PubMed ID | 22340501 | Mgi Jnum | J:181470 |
| Mgi Id | MGI:5311494 | Doi | 10.1016/j.devcel.2011.11.018 |
| Citation | Tam SJ, et al. (2012) Death Receptors DR6 and TROY Regulate Brain Vascular Development. Dev Cell 22(2):403-17 |
| abstractText | Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 and TROY/TNFRSF19 as regulators of CNS-specific angiogenesis in both zebrafish and mice. Furthermore, these two death receptors interact both genetically and physically and are required for vascular endothelial growth factor (VEGF)-mediated JNK activation and subsequent human brain endothelial sprouting in vitro. Increasing beta-catenin levels in brain endothelium upregulate DR6 and TROY, indicating that these death receptors are downstream target genes of Wnt/beta-catenin signaling, which has been shown to be required for BBB development. These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development. |
