| First Author | Tetreault MP | Year | 2013 |
| Journal | Nat Rev Cancer | Volume | 13 |
| Issue | 10 | Pages | 701-13 |
| PubMed ID | 24060862 | Mgi Jnum | J:205154 |
| Mgi Id | MGI:5544162 | Doi | 10.1038/nrc3582 |
| Citation | Tetreault MP, et al. (2013) Kruppel-like factors in cancer. Nat Rev Cancer 13(10):701-13 |
| abstractText | Kruppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with diverse and essential functions in a multitude of cellular processes, including proliferation, differentiation, migration, inflammation and pluripotency. In this Review, we discuss the roles and regulation of the 17 known KLFs in various cancer-relevant processes. Importantly, the functions of KLFs are context dependent, with some KLFs having different roles in normal cells and cancer, during cancer development and progression and in different cancer types. We also identify key questions for the field that are likely to lead to important new translational research and discoveries in cancer biology. |
