| First Author | Allison J | Year | 1988 |
| Journal | Nature | Volume | 333 |
| Issue | 6173 | Pages | 529-33 |
| PubMed ID | 3287175 | Mgi Jnum | J:129442 |
| Mgi Id | MGI:3769279 | Doi | 10.1038/333529a0 |
| Citation | Allison J, et al. (1988) Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 333(6173):529-33 |
| abstractText | A class I histocompatibility gene, H-2Kb, linked to the rat insulin promoter, is overexpressed in the pancreatic beta cells of transgenic mice. The mice, whether syngeneic or allogeneic to the transgene, develop insulin dependent diabetes without detectable T cell infiltration, suggesting a direct, non-immune role for the transgenic class I molecules in the disease process. |
