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Protein Coding Gene : Kif1a kinesin family member 1A

Primary Identifier  MGI:108391 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  16560
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables microtubule binding activity. Predicted to be involved in several processes, including interkinetic nuclear migration; regulation of dendritic spine morphogenesis; and transport along microtubule. Located in neuron projection and neuronal cell body. Is expressed in genitourinary system; nervous system; and sensory organ. Used to study hereditary spastic paraplegia 30. Human ortholog(s) of this gene implicated in NESCAV syndrome; hereditary sensory neuropathy; hereditary sensory neuropathy type 2C; hereditary spastic paraplegia; and hereditary spastic paraplegia 30. Orthologous to human KIF1A (kinesin family member 1A).
PHENOTYPE: Most mice homozygous for a null allele die within a day of birth, with reduced motor and sensory deficits, decreased synaptic vesicle precursor transport, and significant neuronal degeneration in the central nervous system, but two point mutant alleles cause progressive hindleg paralysis [provided by MGI curators]
  • synonyms:
  • N-3 kinesin,
  • RIKEN cDNA C630002N23 gene,
  • Gm1626,
  • kinesin family member 1 (C. elegans unc104 homolog),
  • gene model 1626, (NCBI),
  • C630002N23Rik,
  • MGD-MRK-11590,
  • Kif1a,
  • LOC381283,
  • MGI:2686472,
  • kinesin family member 1A,
  • ATSV,
  • MGD-MRK-37431,
  • Kns1

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

8 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For