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Allele : Pde4d<tm1.1Jmod> phosphodiesterase 4D, cAMP specific; targeted mutation 1.1, James M O'Donnell

Primary Identifier  MGI:6363716 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Pde4d
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  Using homologous recombination, tyrosine codon 271 was changed to a phenylalanine codon (p.Y271F). This mutation humanizes the mouse gene since primates have a Y271. An FRT site flanked neomycin resistance gene cassette that was inserted, was removed through subsequent flp-mediated recombination.
  • mutations:
  • Single point mutation
  • synonyms:
  • hPDE4D,
  • hPDE4D
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele