Primary Identifier | MGI:6363716 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Pde4d |
Transmission | Germline | Strain of Origin | C57BL/6 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Using homologous recombination, tyrosine codon 271 was changed to a phenylalanine codon (p.Y271F). This mutation humanizes the mouse gene since primates have a Y271. An FRT site flanked neomycin resistance gene cassette that was inserted, was removed through subsequent flp-mediated recombination. |