| First Author | Baker SJ | Year | 1995 |
| Journal | Oncogene | Volume | 11 |
| Issue | 3 | Pages | 413-26 |
| PubMed ID | 7630627 | Mgi Jnum | J:28001 |
| Mgi Id | MGI:75635 | Citation | Baker SJ, et al. (1995) B cell differentiation: role of E2A and Pax5/BSAP transcription factors. Oncogene 11(3):413-26 |
| abstractText | Transcriptional regulation of lineage specific genes has the ability to dictate both the proliferative and differentiative potentials of a pluipotent precursor cell. The E2A and Pax5/BSAP genes encode transcription factors which bind to B cell specific promoters and enhancers and guide the development of immature, but committed cells into mature B lymphocytes which express and secrete immunoglobulins. In vitro analysis has consistently suggested that these proteins regulate distinct classes of genes during B cell differentiation; however, recent targeted gene disruption and transgene expression in mice has indicated that these genes may actually be components of a single regulatory mechanism which is essential for both B lymphocyte differentiation and proliferation. |
