| First Author | Zako M | Year | 1995 |
| Journal | J Biol Chem | Volume | 270 |
| Issue | 8 | Pages | 3914-8 |
| PubMed ID | 7876137 | Mgi Jnum | J:23147 |
| Mgi Id | MGI:70934 | Doi | 10.1074/jbc.270.8.3914 |
| Citation | Zako M, et al. (1995) Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues. J Biol Chem 270(8):3914-8 |
| abstractText | We showed previously that the alternative splicing of chondroitin sulfate attachment domains (CS alpha and CS beta) yielded multiforms of the PG-M core protein in mouse. A transcript encoding a new short form of the core protein PG-M(V3) was found in various mouse tissues using polymerase chain reaction. DNA sequences of the polymerase chain reaction products suggested that PG-M(V3) had no chondroitin sulfate attachment domain. PG-M(V3) was also detected in various human tissues. The presence of a transcript for PG-M(V3) was further supported by Northern blot analysis. Southern blot analysis confirmed that multiforms of the PG-M core protein, including PG-M(V3), were derived from a single genomic locus by an alternative splicing mechanism. Because PG-M(V3) has no chondroitin sulfate attachment region, which is the most distinctive portion of a proteoglycan molecule, this form may have a unique function. |
