| Primary Identifier | MGI:1916288 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 69038 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables oligosaccharyltransferase complex binding activity. Acts upstream of or within several processes, including epithelial cell apoptotic process; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of oligosaccharyltransferase I complex. Predicted to be active in membrane-bounded organelle. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TMEM258 (transmembrane protein 258). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality while heterozygotes exhibit increased susceptibility to DSS-induced colitis associated with increased endoplasmic reticulum (ER) stress. Homozygous deficiency in colonic organoids results in unresolved ER stress and apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
