| First Author | Sato F | Year | 2017 |
| Journal | Sci Rep | Volume | 7 |
| Issue | 1 | Pages | 10496 |
| PubMed ID | 28874814 | Mgi Jnum | J:256528 |
| Mgi Id | MGI:6108921 | Doi | 10.1038/s41598-017-10980-0 |
| Citation | Sato F, et al. (2017) T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection. Sci Rep 7(1):10496 |
| abstractText | Intracerebral Theiler''s murine encephalomyelitis virus (TMEV) infection in mice induces inflammatory demyelination in the central nervous system. Although C57BL/6 mice normally resistant to TMEV infection with viral clearance, we have previously demonstrated that RORgammat-transgenic (tg) C57BL/6 mice, which have Th17-biased responses due to RORgammat overexpression in T cells, became susceptible to TMEV infection with viral persistence. Here, using T-bet-tg C57BL/6 mice and Gata3-tg C57BL/6 mice, we demonstrated that overexpression of T-bet, but not Gata3, in T cells was detrimental in TMEV infection. Unexpectedly, T-bet-tg mice died 2 to 3 weeks after infection due to failure of viral clearance. Here, TMEV infection induced splenic T cell depletion, which was associated with lower anti-viral antibody and T cell responses. In contrast, Gata3-tg mice remained resistant, while Gata3-tg mice had lower IFN-gamma and higher IL-4 production with increased anti-viral IgG1 responses. Thus, our data identify how overexpression of T-bet and Gata3 in T cells alters anti-viral immunity and confers susceptibility to TMEV infection. |
