Primary Identifier | MGI:1856054 | Allele Type | Spontaneous |
Attribute String | Null/knockout | Gene | Ift56 |
Inheritance Mode | Recessive | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The molecular lesion is a C-to-A point mutation (c.1290C>A) that changes a tyrosine codon to a stop codon (p.Y430*) in exon 15. This mutation arose spontaneously in an unirradiated stock at the MRC Radiobiology Unit at Harwell in 1967. RT-PCR indicates expression of the mRNA was reduced 5.7-fold compared to that of the wild-type mRNA in MEFs. |