| First Author | Rinn JL | Year | 2008 |
| Journal | Genes Dev | Volume | 22 |
| Issue | 3 | Pages | 303-7 |
| PubMed ID | 18245445 | Mgi Jnum | J:131546 |
| Mgi Id | MGI:3773949 | Doi | 10.1101/gad.1610508 |
| Citation | Rinn JL, et al. (2008) A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev 22(3):303-7 |
| abstractText | Reciprocal epithelial-mesenchymal interactions shape site-specific development of skin. Here we show that site-specific HOX expression in fibroblasts is cell-autonomous and epigenetically maintained. The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including expression of WNT5A, a morphogen required for distal development. The ability of distal fibroblasts to induce epidermal keratin 9, a distal-specific gene, is abrogated by depletion of HOXA13, but rescued by addition of WNT5A. Thus, maintenance of appropriate HOX transcriptional program in adult fibroblasts may serve as a source of positional memory to differentially pattern the epithelia during homeostasis and regeneration. |
