| Primary Identifier | MGI:6275008 | Allele Type | Transgenic |
| Attribute String | Dominant negative, Inserted expressed sequence, Reporter | Gene | Tg(Myh6-Kcnj8*/EGFP)1Wco |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The alpha-myosin heavy chain promoter drives cardiac-specific expression of a dominant negative rat Kcnj8 mutant, in which the subunit pore region was mutated from glycine-phenylalanine-glycine to three alanines, with a COOH-terminal enhanced green fluorescent protein. RT-PCR and Western blotting confirmed expression of the transgene specifically in the heart. Several lines were made but only one was further analyzed. |
