| First Author | Asin KE | Year | 1992 |
| Journal | Pharmacol Biochem Behav | Volume | 42 |
| Issue | 4 | Pages | 699-704 |
| PubMed ID | 1513850 | Mgi Jnum | J:2192 |
| Mgi Id | MGI:50716 | Doi | 10.1016/0091-3057(92)90017-a |
| Citation | Asin KE, et al. (1992) A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey. Pharmacol Biochem Behav 42(4):699-704 |
| abstractText | The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-71623, were examined in CD1 mice, beagle dogs, and cynomolgus monkeys. A-71623 suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to A-71623, although the effects of both CCK agonists were more short-lived in the dog compared to the other species tested. Our results support other evidence suggesting that the anorectic actions of exogenous application of CCK-8 in these species are mediated via stimulation of the CCK-A receptor subtype. |
