| Primary Identifier | MGI:97379 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 20493 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to act upstream of or within lipid transport and sodium ion transport. Located in membrane. Is expressed in liver. Orthologous to human SLC10A1 (solute carrier family 10 member 1). PHENOTYPE: Mice homozygous for a knock-out allele show impaired hepatic uptake of conjugated bile acids (BAs) and Myrcludex B binding. A subset of adult homozygotes exhibit hypercholanemia, reduced body weight, increased serum alkaline phosphatase and bilirubin levels but no overt liver damage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
