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Publication : The uptake of cholesterol at the small-intestinal brush border membrane is inhibited by apolipoproteins.

First Author  Boffelli D Year  1997
Journal  FEBS Lett Volume  411
Issue  1 Pages  7-11
PubMed ID  9247133 Mgi Jnum  J:41695
Mgi Id  MGI:894225 Doi  10.1016/s0014-5793(97)00658-3
Citation  Boffelli D, et al. (1997) The uptake of cholesterol at the small-intestinal brush border membrane is inhibited by apolipoproteins. FEBS Lett 411(1):7-11
abstractText  The uptake of free and esterified cholesterol at the brush border membrane is protein-mediated. Here we show that this sterol uptake is effectively inhibited by exchangeable serum apolipoproteins. Binding of the apolipoprotein to the brush border membrane mediates the inhibitory effect. Evidence is presented to show that the structural motif responsible for the inhibition is the amphipathic alpha-helix.
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