Primary Identifier | MGI:1934924 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Dcc |
Transmission | Germline | Strain of Origin | 129S2/SvPas |
Is Recombinase | false | Is Wild Type | false |
description | Homozygous mutant mice have defective axonal projections of neural cells similar to those observed in null mutations for the netrin gene, Ntn1, but with no effects on intestine or on tumorigenesis within the intestine (J:39765). |
molecularNote | A neomycin resistance cassette was inserted into exon 3. Immunoprecipitation experiments demonstrated that no full length protein was produced from this allele in homozygous mice. |