| Primary Identifier | MGI:101932 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 12876 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables metallocarboxypeptidase activity. Involved in insulin processing. Acts upstream of or within peptide hormone secretion and protein localization to secretory granule. Located in secretory granule membrane. Is active in secretory granule. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study obesity. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E). PHENOTYPE: Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
