| First Author | Korsmeyer SJ | Year | 1995 |
| Journal | Trends Genet | Volume | 11 |
| Issue | 3 | Pages | 101-5 |
| PubMed ID | 7732571 | Mgi Jnum | J:23747 |
| Mgi Id | MGI:71438 | Doi | 10.1016/S0168-9525(00)89010-1 |
| Citation | Korsmeyer SJ (1995) Regulators of cell death. Trends Genet 11(3):101-5 |
| abstractText | A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic pathway of cellular suicide that appears to be common to all multicellular animals. A related protein that promotes cell death, Bax, wrestles with Bcl-2 through conserved motifs, BH1 and BH2, establishing a set point for these deaths. In Bcl-2-deficient mice, the ratio of these molecules is reset, resulting in massive cell death in several cell types. |
