| First Author | Liu C | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 436 |
| Issue | 1 | Pages | 47-52 |
| PubMed ID | 23707719 | Mgi Jnum | J:203222 |
| Mgi Id | MGI:5525204 | Doi | 10.1016/j.bbrc.2013.05.054 |
| Citation | Liu C, et al. (2013) Id1 expression promotes peripheral CD4+ T cell proliferation and survival upon TCR activation without co-stimulation. Biochem Biophys Res Commun 436(1):47-52 |
| abstractText | Although the role of E proteins in the thymocyte development is well documented, much less is known about their function in peripheral T cells. Here we demonstrated that CD4 promoter-driven transgenic expression of Id1, a naturally occurring dominant-negative inhibitor of E proteins, can substitute for the co-stimulatory signal delivered by CD28 to facilitate the proliferation and survival of naive CD4+ cells upon anti-CD3 stimulation. We next discovered that IL-2 production and NF-kappaB activity after anti-CD3 stimulation were significantly elevated in Id1-expressing cells, which may be, at least in part, responsible for the augmentation of their proliferation and survival. Taken together, results from this study suggest an important role of E and Id proteins in peripheral T cell activation. The ability of Id proteins to by-pass co-stimulatory signals to enable T cell activation has significant implications in regulating T cell immunity. |
