| First Author | Pan X | Year | 2015 |
| Journal | Reproduction | Volume | 149 |
| Issue | 4 | Pages | 385-91 |
| PubMed ID | 25628439 | Mgi Jnum | J:222054 |
| Mgi Id | MGI:5643900 | Doi | 10.1530/REP-14-0231 |
| Citation | Pan X, et al. (2015) Ppp2ca knockout in mice spermatogenesis. Reproduction 149(4):385-91 |
| abstractText | Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase involved in meiosis, mitosis, sperm capacitation, and apoptosis. Abberant activity of PP2A has been associated with a number of diseases. The homolog PPP2CA and PPP2CB can each function as the phosphatase catalytic subunit generally referred to as PP2AC. We generated a Ppp2ca conditional knockout (CKO) in C57BL/6J mice. Exon 2 of Ppp2ca was knocked out in a spatial or temporal-specific manner in primordial germ cells at E12.5. This Ppp2ca-null mutation caused infertility in male C57BL/6J mice. These CKO mice provide a powerful tool to study the mechanisms of Ppp2ca in development and disease. |
