| Type | MGI:General | Description | 70% of mutants challenged with A. fumigatus spores died by day 15; only 20% of wild-type died during the same period only 30% of mutants survived beyond 30 days of observation, whereas 60% of control mice remained healthy fatally infected mice from both groups exhibited severe ataxia associated with fungal invasion of the CNS 2-3 days prior to death; these symptoms were detected at least 2-3 days earlier in mutants relative to wild-type mutants injected with 107 spores exhibited extensive hyphal growth in the kidney, lung, liver, and brain 24 hours after injection; no growth was detected in the brain and lungs of wild-type mice until 72 hours after injection none of the infected organs showed hyphal invasion of blood vessels |
