| Primary Identifier | IPR032565 | Type | Domain |
| Short Name | NCOA2/3_DUF4927 |
| description | This entry represents a domain found in Nuclear receptor coactivators 2/3 (NCOA2/3), which are ligand-dependent transcription factors []. NCOA2 is a transcriptional coactivator for steroid receptors and nuclear receptors. It functions as a coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) []. Together with NCOA1, it is required to control energy balance between white and brown adipose tissues []. NCOA3 is overexpressed in a fraction of breast cancers and has been linked to prognosis and tamoxifen resistance [, , ]. |
