| First Author | Kishi M | Year | 2005 |
| Journal | Science | Volume | 307 |
| Issue | 5711 | Pages | 929-32 |
| PubMed ID | 15705853 | Mgi Jnum | J:96030 |
| Mgi Id | MGI:3528781 | Doi | 10.1126/science.1107403 |
| Citation | Kishi M, et al. (2005) Mammalian SAD kinases are required for neuronal polarization. Science 307(5711):929-32 |
| abstractText | Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons-their dendrites and axons-are thus related to their fundamental functions: the receipt and transmission of information. The acquisition of these distinct properties by dendrites and axons, called polarization, is a critical step in neuronal differentiation. We show here that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization. These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons. |
