| First Author | Kiehl TR | Year | 2006 |
| Journal | Biochem Biophys Res Commun | Volume | 339 |
| Issue | 1 | Pages | 17-24 |
| PubMed ID | 16293225 | Mgi Jnum | J:103805 |
| Mgi Id | MGI:3610752 | Doi | 10.1016/j.bbrc.2005.10.186 |
| Citation | Kiehl TR, et al. (2006) Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochem Biophys Res Commun 339(1):17-24 |
| abstractText | Ataxin-2, the gene product of the Spinocerebellar Ataxia Type 2 (SCA2) gene, is a protein of unknown function with abundant expression in embryonic and adult tissues. Its interaction with A2BP1/Fox-1, a protein with an RNA recognition motif, suggests involvement of ataxin-2 in mRNA translation or transport. To study the effects of in vivo ataxin-2 function, we generated an ataxin-2 deficient mouse strain. Ataxin-2 deficient mice were viable. Genotypic analysis of litters from mating of heterozygous mice showed segregation distortion with a significant reduction in the birth of Sca-/- females. Detailed macroscopic and microscopic analysis of surviving nullizygous Sca2 knockout mice showed no major histological abnormalities. On a fat-enriched diet, ataxin-2 deficient animals had increased weight gain. Our results demonstrate that ataxin-2, although widely expressed, is not essential in development or during adult survival in the mouse, but leads to adult-onset obesity. |
