| Primary Identifier | IPR015754 | Type | Family |
| Short Name | Ca-bd_2 |
| description | Calcium-binding proteins (CaBPs) are a family of Ca(2+)-binding proteins related to calmodulin with strong sequence similarity to Calmodulin (CaM), which is an important component of Ca(2+)-mediated cellular signal transduction in the central nervous system []. Like calmodulin, CaBP family members regulate effectors such as voltage-gated Ca2+ channels in a Ca2+-dependentmanner [, ]. CaBPs are localised in the brain and sensory organs. Mutations in calcium-binding protein 2 (CaBP2) cause hearing loss, revealing a role for CaBP2 in the mammalian auditory system [].This entry represents Calcium-binding protein 2 (Cabp2) which inhibits the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in (IHCs), required for sound encoding at these cells synapses []and it is also involved in the proper transmission of light signals through the retina []. |
