| First Author | Tutois S | Year | 1991 |
| Journal | Mamm Genome | Volume | 1 |
| Issue | 3 | Pages | 184-90 |
| PubMed ID | 1797233 | Mgi Jnum | J:11633 |
| Mgi Id | MGI:60027 | Doi | 10.1007/BF00351065 |
| Citation | Tutois S, et al. (1991) Tg (9 HSA-MYC), a homozygous lethal insertion in the mouse. Mamm Genome 1(3):184-90 |
| abstractText | Transgenic mice generated with different DNA sequences were surveyed for possible homozygous mutant phenotypes. We found an embryonic lethal mutation in the transgenic mouse strain (MT-MYC12.4) containing the human c-myc gene. Embryos homozygous for the transgene die shortly after implantation. The strain MT-MYC12.4 carries approximately 50 tandem copies of the recombinant plasmid sequence. The 3' flanking sequence has been cloned and analyzed. It contains a unique sequence that has been conserved during evolution and maps to Chromosome (Chr) 9. This mutant has been designated Tg 9 (HSA-MYC). |
