| First Author | Massey PV | Year | 2003 |
| Journal | Neuropharmacology | Volume | 44 |
| Issue | 1 | Pages | 40-8 |
| PubMed ID | 12559120 | Mgi Jnum | J:97043 |
| Mgi Id | MGI:3574177 | Doi | 10.1016/s0028-3908(02)00297-6 |
| Citation | Massey PV, et al. (2003) Galanin regulates spatial memory but not visual recognition memory or synaptic plasticity in perirhinal cortex. Neuropharmacology 44(1):40-8 |
| abstractText | It has previously been shown that the neuropeptide galanin plays a role in the age-dependent regulation of hippocampal synaptic plasticity and spatial memory. Here, we further extend these studies by demonstrating that galanin knockout mice also have deficits in an object-in-place spatial memory task. In contrast however, there is no deficit in single item object recognition memory, a memory that depends on perirhinal cortex. Furthermore, in perirhinal cortex slices there are no differences in activity-dependent long-term potentiation or depotentiation, nor in muscarinic receptor-dependent long-term depression between galanin knockout mice and wild-type litter-mates. Therefore, these results suggest that galanin has a differential role in hippocampal-dependent and perirhinal cortex-dependent memory. |
