| First Author | Jordan MS | Year | 2001 |
| Journal | Nat Immunol | Volume | 2 |
| Issue | 4 | Pages | 301-6 |
| PubMed ID | 11276200 | Mgi Jnum | J:133154 |
| Mgi Id | MGI:3777871 | Doi | 10.1038/86302 |
| Citation | Jordan MS, et al. (2001) Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol 2(4):301-6 |
| abstractText | Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4+CD25+ regulatory T cells. Selection of CD4+CD25+ thymocytes appears to require a TCR with high affinity for a self peptide because thymocytes that bear TCRs with low affinity do not undergo selection into this pathway. Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion. |
