Primary Identifier | MGI:1858014 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Msh6 |
Transmission | Germline | Strain of Origin | STOCK 129/Sv and C57BL/6J and SJL |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin resistance gene was inserted at codon 336 within exon 4 of the gene, resulting in a stop codon 21 nucleotides downstream. No transcript for the targeted gene was detected on Northern blots of RNA extracted from two double-targeted ES cell lines. No protein product for the targeted gene was detected on Western blots of protein extracted from two double-targeted ES cell lines. |