| Primary Identifier | MGI:5308396 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(Thy1-DCTN1*G59S)M2Pcw |
| Strain of Origin | (C57BL/6 x SJL)F1 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | This transgene contains the mouse Thy1 (thymus cell antigen 1, theta, promoter (Thy1.2)) promoter driving expression of the full-length human dynactin 1 (DCTN1) cDNA sequence. A missense mutation associated with amyotrophic lateral sclerosis (ALS), G59S, was introduced into dynactin cDNA encoding the p150 subunit. A FLAG tag was also introduced at the C-terminal. Line M2 was generated. |
