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Allele : Gt(ROSA)26Sor<tm8(CAG-CHRM3*)Jcbr> gene trap ROSA 26, Philippe Soriano; targeted mutation 8, Jens C Bruning
Primary Identifier  MGI:7485775 Allele Type  Targeted
Attribute String  Conditional ready, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  B6.Cg-Thy1<a>
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting construct contained the CAG promoter (chicken beta actin promoter with CMV enhancers), a floxed neomycin-Westphal stop sequence (WSS) cassette, and a modified Gq-coupled human M3 muscarinic receptor (CHRM3) gene. The wild-type human muscarinic 3 receptor sequence was modified via site-directed mutagenesis to harbor two amino acid substitutions (Y149C and A239G) that abolish receptor affinity for the native ligand, acetylcholine (ACh), but allow receptor binding and subsequent activation by the small drug-like molecule clozapine-N-oxide (CNO).
  • mutations:
  • Insertion
  • synonyms:
  • ROSA26CAGSloxSTOPloxhMD3Gq,
  • ROSA26CAGSloxSTOPloxhMD3Gq
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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1 Driven By

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11 Publication categories

Trail: Allele




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