| First Author | Cortinas MN | Year | 2001 |
| Journal | Mol Biol Evol | Volume | 18 |
| Issue | 9 | Pages | 1643-53 |
| PubMed ID | 11504845 | Mgi Jnum | J:71095 |
| Mgi Id | MGI:2149175 | Doi | 10.1093/oxfordjournals.molbev.a003953 |
| Citation | Cortinas MN, et al. (2001) Molecular evolution of Aldolase A pseudogenes in mice: multiple origins, subsequent duplications, and heterogeneity of evolutionary rates. Mol Biol Evol 18(9):1643-53 |
| abstractText | The Aldolase multigene family comprises three functional genes (A, B, and C) with tissue-specific expression regulated during ontogeny. DGGE analysis and nucleotide sequencing reveal a family of retropseudogenes of type A in species of MUS: Significant variation in rates of evolution of Aldolase A retropseudogenes is apparent. Our analyses demonstrate that (1) multiple events of retrotransposition are needed to account for the diversity of Aldolase A processed pseudogenes found in mice; (2) some of these sequences have undergone further duplication subsequent to the original retrotransposition event; (3) the patterns of nucleotide substitution are broadly comparable with previous estimates; and (4) estimates of rates of divergence for this array of sequences are up to four times higher than those reported in the literature. |
