| First Author | Parnet P | Year | 1996 |
| Journal | J Biol Chem | Volume | 271 |
| Issue | 8 | Pages | 3967-70 |
| PubMed ID | 8626725 | Mgi Jnum | J:31466 |
| Mgi Id | MGI:78974 | Doi | 10.1074/jbc.271.8.3967 |
| Citation | Parnet P, et al. (1996) IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem 271(8):3967-70 |
| abstractText | A novel member of the interleukin-1 receptor family has been cloned by polymerase chain reaction using degenerate oligonucleotide primers derived from regions of sequence conservation, using as template a yeast artificial chromosome known to contain both interleukin-1 (IL-1) receptors and T1/ST2. The new receptor, called IL-1 receptor-related protein or IL-1Rrp, fails to bind any of the known IL-1 ligands. A chimeric receptor, in which the IL-1Rrp cytoplasmic domain is fused to the extracellular and transmembrane regions of the IL-1 receptor, responds to IL-1 following transfection into COS cells by activation of NFkappaB and induction of IL-8 promoter function. |
