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Comment :

Type  MGI:General Description  sodium current recordings show that peak current densities are 30-40% higher in ventricular myocytes, a 30-40% higher conductance, and slower recovery time from inactivation while wild-type ventricles have a predominately left-right activation pattern (94%) at E18.5, mutant hearts maintain a left ventricular activation pattern (84%), indicating abnormal ventricular activation pattern during development under spontaneous rhythm, mice show an increase in total left ventricular activation time at E18.5 and in adults, but not at E14.5, indicating a delay in the transmission of the electrical impulse